MD MRCP(UK) MRCP(Gastro) FEBGH MD(Res)(Advanced Endoscopy)(Imperial)

Registration & Memberships

Registration and licensing

  • GMC Number 6095124

Memberships and associations

  • BSG
  • ESGE
  • ASGE
  • European Crohn’s and Colitis Organisation (ECCO)

Languages Spoken

  • English

Dr Edward Despott

Consultant gastroenterologist and advanced GI endoscopist

MD MRCP(UK) MRCP(Gastro) FEBGH MD(Res)(Advanced Endoscopy)(Imperial)

Dr Edward J. Despott is the Trust-wide Service Line Lead for Endoscopy at the Royal Free Unit for Endoscopy, Royal Free NHS Foundation Trust and UCL Institute for Liver and Digestive Health (Royal Free campus) in Hampstead, London. Through this position, he is in charge of endoscopy services delivered at 3 hospitals comprising the Royal Free London NHS Foundation Trust, namely The Royal Free Teaching Hospital, and Barnet, and Chase Farm Hospitals. He is a consultant gastroenterologist and advanced gastrointestinal (GI) endoscopist whose specialist interests include device assisted enteroscopy (double-balloon enteroscopy (DBE) in particular), capsule endoscopy (CE), therapeutic colonoscopy (particularly complex polypectomy including large endoscopic mucosal resection (EMR) and endoscopic submucosal dissection ESD)) and transnasal upper GI endoscopy. He is also interested in the diagnosis and management of inflammatory bowel disease and related complications (such as endoscopic management of small bowel and colonic strictures). Since his appointment in 2012, Dr Despott instigated significant advances at the Royal Free Unit for Endoscopy by making it one of the only 2 centres in London (and one of a handful in the UK) to offer a comprehensive small bowel endoscopy service including DBE and the development of a tertiary advanced polypectomy service.

Dr Despott is regularly invited to speak and perform live endoscopy demonstrations at national and international meetings and was recently awarded a bursary by the Japanese GI Endoscopy Society (JGES) to present his work at the 85th JGES Congress held in Kyoto, Japan in May 2013.The British Society of Gastroenterology (BSG) has also recently awarded Dr Despott another travelling fellowship to Japan and throughout the month of November 2012 he underwent further training in advanced GI endoscopic techniques including ESD and therapeutic DBE at the National Cancer Centre in Tokyo and the Jichi Medical University, Tochigi Japan, under the direct mentorship of Dr Yutaka Saito and Prof Hironori Yamamoto, respectively. In 2007 Dr Despott was also awarded a prestigious scholarship to undergo advanced endoscopy training (particularly in DBE, CE and advanced therapeutic colonoscopy) at the Wolfson Unit for Endoscopy at St Mark’s Hospital and Academic Institute (a World Endoscopy Organisation (WEO) centre of excellence). He spent a total of 3½ years of dedicated endoscopy training at the Wolfson Unit at St Mark’s, during which time he also undertook formal research at the same institution and Imperial College London towards an MD(Research) thesis entitled ‘Advancing Minimally Invasive Aspects of Digestive Endoscopy’. He continues to be actively involved in endoscopic research and currently forms part of the European Society of Gastrointestinal Endoscopy (ESGE) guidelines committee for small bowel endoscopy. Dr Despott has published numerous (>20) scientific peer-reviewed papers, several book chapters and review articles and regularly acts as a referee for scientific journals of high impact. His work is also regularly accepted for oral presentation at national and international conferences. He also maintains an active interest in endoscopy education and teaches on several hands-on endoscopy courses, and forms part of the faculty of the ‘European Capsule Endoscopy Course’ (also endorsed by the BSG and American Society of Gastrointestinal Endoscopy (ASGE)).

Dr Despott qualified from the University of Malta in 1999, after which he moved to the UK to pursue higher specialist training in gastroenterology and GI endoscopy. He obtained MRCP(UK) in 2003 and subsequently trained in gastroenterology in the North East Thames rotation of the London Deanery School of Medicine. He obtained MRCP(Gastro) in 2010 and on completion of his higher specialist training, he was appointed to the attending consultant staff at the Royal Free in 2012, where he immediately established new advanced endoscopy services. In 2013 he was appointed to the position of Clinical Lead of Endoscopy and in 2014 (on acquisition of Barnet and Chase Farm hospitals by the Royal Free), he was put in charge of all endoscopy services delivered at the Trust’s 3 hospitals.

He is an active member of the BSG, ESGE, ASGE and the European Crohn’s and Colitis Organisation (ECCO) and was elected as a Fellow of the European Board of Gastroenterology and Hepatology (FEBGH) in 2012. Dr Despott also enjoys painting seascapes in oils, photography and deep-sea fishing.



Special interests:

Dr Despotts main specialist interest is advanced GI endoscopy including:

  • Device assisted enteroscopy (double-balloon enteroscopy (DBE) in particular)
  • Capsule endoscopy (CE)
  • Therapeutic colonoscopy (particularly complex polypectomy including large endoscopic mucosal resection (EMR)) and transnasal upper GI endoscopy.
  • Dr Despott is also interested in the diagnosis and management of inflammatory bowel disease and related complications such as Endoscopic management of small bowel and colonic strictures.
Published papers:

Dark macules in the upper gastrointestinal tract: An ominous sign. Laskaratos FM, Gillmore R, Clark I, Despott. EJ. Dig Liver Dis. 2014 Aug 14. pii: S1590-8658(14)00444-7.

Factors associated with reduced insertion depth at double balloon enteroscopy: A retrospective, multivariate analysis.Murino A, Nakamura M, Despott EJ, Fraser C. Dig Liver Dis. 2014 Jun 26. pii: S1590-8658(14)00399-5.

Fatal enteritis in a renal transplant patient with post-transplant thrombotic microangiopathy undergoing plasma exchange therapy. Owen L, Jones G, Despott EJ, Murray C, Atkinson C, Beal I, Webster DP. J Clin Virol. 2014 Apr;59(4):213-7.

Favorable long-term outcomes of repeat endotherapy for small-intestine vascular lesions by double-balloon endoscopy. Shinozaki S, Yamamoto H, Yano T, Sunada K, Hayashi Y, Shinhata H, Sato H, Despott EJ, Sugano K. Gastrointest Endosc. 2014 Jul;80(1):112-7.

Is there a role for emergency small bowel capsule endoscopy in the investigation and management of severe obscure-overt gastrointestinal bleeding? Despott EJ. Ann Gastroenterol. 2013;26(2):178-179.

Endoscopic features of mesenteric panniculitis by double-balloon enteroscopy. Bourikas LA, Despott EJ, Moorghen M, Fraser C. Dig Liver Dis. 2012 Nov;44(11):961. doi: 10.1016/j.dld.2012.06.001.

Small bowel endoscopy in inflammatory bowel disease. Despott EJ, Fraser C. Best Pract Res Clin Gastroenterol. 2012 Jun;26(3):279-91.

A rare case of small bowel intussusception. Murino A, Despott EJ, Hansmann A, Heath P, Fraser C. Endoscopy. 2012;44 Suppl 2 UCTN:E157-8.

Tracheal aspiration of capsule endoscopes: detection, management, and susceptibility. Despott EJ, O’Rourke A, Anikin V, Davison C, Panter S, Bromley J, Plaice J, Corbett M, Fraser C. Dig Dis Sci. 2012 Jul;57(7):1973-4.

First report of endoscopic closure of a gastrocolic fistula using an over-the-scope clip system (with video). Murino A, Despott EJ, Vaizey C, Bashir G, Hansmann A, Gupta A, Konieczko K, Fraser C. Gastrointest Endosc. 2012 Apr;75(4):893; discussion 894.

Management of deep looping when failing to progress at double-balloon enteroscopy. Despott EJ, Murino A, Fraser C.Endoscopy. 2011;43 Suppl 2 UCTN:E275-6.

First report of a secondary aortojejunal fistula visualized by small bowel capsule endoscopy. Despott EJ, Murino A, Butcher J, Hussain T, Greenstein D, Naji Y, O’Rourke A, Fraser C. Dig Dis Sci. 2012 Jan;57(1):256-7.

An unusual finding at screening colonoscopy: polypoid follicular lymphoma with marginal zone differentiation. Despott EJ, Tadrous PJ, Naresh KN, Savio A, Marshall M, Saunders BP. Endoscopy. 2011;43 Suppl 2 UCTN:E266-7.

Enteral access by double-balloon enteroscopy: an alternative method of direct percutaneous endoscopic jejunostomy placement. Despott EJ, Gabe S, Tripoli E, Konieczko K, Fraser C. Dig Dis Sci. 2011 Feb;56(2):494-8.

First cases of spiral enteroscopy in the UK: let’s “torque” about it! Despott EJ, Hughes S, Marden P, Fraser C. Endoscopy. 2010 Jun;42(6):517.

Sedation in digestive endoscopy: the Athens international position statements. Cohen LB, Ladas SD, Vargo JJ, Paspatis GA, Bjorkman DJ, Van der Linden P, Axon AT, Axon AE, Bamias G, Despott E, Dinis-Ribeiro M, Fassoulaki A, Hofmann N, Karagiannis JA, Karamanolis D, Maurer W, O’Connor A, Paraskeva K, Schreiber F, Triantafyllou K, Viazis N, Vlachogiannakos J. Aliment Pharmacol Ther. 2010 Aug;32(3):425-42.

Advanced cardiac life support training. Despott EJ, Schreiber F. Digestion. 2010;82(2):113-4. doi: 10.1159/000285587. Epub 2010 Apr 21.

Achieving successful ileal intubation during retrograde double balloon enteroscopy: description of a novel, alternative technique (with video). Despott E, Fraser C. Endoscopy. 2009;41 Suppl 2:E309-10.

Effective dilation of small-bowel strictures by double-balloon enteroscopy in patients with symptomatic Crohn’s disease (with video). Despott EJ, Gupta A, Burling D, Tripoli E, Konieczko K, Hart A, Fraser C. Gastrointest Endosc. 2009 Nov;70(5):1030-6. doi: 10.1016/j.gie.2009.05.005. Epub 2009 Jul 28.

Role of small-bowel endoscopy in the management of patients with inflammatory bowel disease: an international OMED-ECCO consensus. Bourreille A, Ignjatovic A, Aabakken L, Loftus EV Jr, Eliakim R, Pennazio M, Bouhnik Y, Seidman E, Keuchel M, Albert JG, Ardizzone S, Bar-Meir S, Bisschops R, Despott EJ, Fortun PF, Heuschkel R, Kammermeier J, Leighton JA, Mantzaris GJ, Moussata D, Lo S, Paulsen V, Panés J, Radford-Smith G, Reinisch W, Rondonotti E, Sanders DS, Swoger JM, Yamamoto H, Travis S, Colombel JF, Van Gossum A; World Organisation of Digestive Endoscopy (OMED) and the European Crohn’s and Colitis Organisation (ECCO). Endoscopy. 2009 Jul;41(7):618-37.

An unusual cause of diarrhea: diffuse intestinal nodular lymphoid hyperplasia in association with selective immunoglobulin A deficiency (with video). Postgate A, Despott E, Talbot I, Phillips R, Aylwin A, Fraser C. Gastrointest Endosc. 2009 Jul;70(1):168-9; discussion 169.

Significant small-bowel lesions detected by alternative diagnostic modalities after negative capsule endoscopy. Postgate A, Despott E, Burling D, Gupta A, Phillips R, O’Beirne J, Patch D, Fraser C. Gastrointest Endosc. 2008 Dec;68(6):1209-14.

Antibiotic therapy: a major cause of drug-induced jaundice in southwest England. Hussaini SH, O’Brien CS, Despott EJ, Dalton HR. Eur J Gastroenterol Hepatol. 2007 Jan;19(1):15-20.

Dr Edward Despott, Consultant Gastroenterologist, is available to be seen for consultations at the Royal Free and Hadley Wood Hospital.