Mr Reza Mirnezami

MBBS, BSC, FRCS, PHD

Consultant Colorectal Surgeon

Mr Mirnezami is a consultant colorectal surgeon and is the Clinical Director for Colorectal, General and Emergency Surgery at the Royal Free Hospital. Mr Mirnezami offers treatment for all benign and malignant conditions of the small intestine, large intestine and anus, as well as general surgery conditions such as abdominal wall hernia. He leads the Colorectal Cancer MDT and his practice is primarily focused on the operative management of colorectal cancer and neuroendocrine tumours of the midgut. He performs a high volume of laparoscopic (‘keyhole’) procedures for colorectal cancer and also performs a high volume of surgical procedures for neuroendocrine tumours, for which he is a key opinion leader and tertiary referral specialist, receiving referrals from all over the United Kingdom.

Mr Mirnezami is firmly committed to evidence-based medicine and has several active areas of ongoing research focused on colorectal and neuroendocrine tumours. He holds a doctoral degree awarded by Imperial College London for his PhD thesis, supervised by Lord Ara Darzi, which evaluated colorectal cancer metabolism. He has published over 80 manuscripts in scientific journals, including the New England Journal of Medicine, Lancet Oncology, Annals of Surgery and Nature. He has authored 7 book chapters on wide ranging clinical topics including surgical oncology, robotic surgery, and artificial intelligence in healthcare. Mr Mirnezami is passionate about the role of personalised healthcare initiatives in treating patients with cancer, and previously served on the World Economic Forum (WEF) Precision Medicine Council, producing a WEF white-paper on the subject, entitled 'Preparing for Precision Medicine'.

Mr Mirnezami's work in the field of neuroendocrine tumours has received national recognition and he currently serves as a committee member for the UK and Ireland Neuroendocrine Tumour Society (UKI-NETS).

Hospital Locations

Royal Free Hospital

Year qualified

2004

Country of qualification

Languages spoken

English and Farsi

Specialities

Colorectal Surgery
General Surgery

Memberships

Royal College of Surgeons of England (RCSEng)
Association of Coloproctology of Great Britain & Ireland (ACPGBI)

Registration and licensing

GMC:6104730

Procedures offered

Laparoscopic and open surgery for colon cancer and rectal cancer
Laparoscopic and open surgery for inflammatory bowel disease (including but not limited to Crohn’s disease and ulcerative colitis)
Open abdominal wall hernia surgery (including but not limited to inguinal, femoral, umbilical, epigastric and incisional hernia)
Surgery for haemorrhoids (including Milligan-Morgan haemorrhoidectomy, Ligasure haemorrhoidectomy, THD and rubber band ligation)
Surgery for fissure in ano
Surgery for fistula in ano

Clinical interests

My main area of clinical interest is colorectal cancer and I run parallel streams of clinical and translational research in this area with the hope of enhancing patient survival. I am also highly trained in the operative and non-operative management of inflammatory bowel diseases including Crohn’s and ulcerative colitis.

Research interests

I am passionate about clinical and translational research and I currently have an active research portfolio focused on colorectal cancer metabolism. I was awarded a PhD in 2013 for a project evaluating the role of metabolic phenotyping approaches (NMR spectroscopy and mass spectrometry) in colorectal cancer.

Published papers

Mirnezami R, Soares A, Chand M. Enhancing the precision of circular stapled colorectal anastomosis: could powered stapler technology provide the solution? Tech Coloproctol. 2019 Jul;23(7):687-689.
Veselkov K, Gonzalez G, Aljifri S, Galea D, Mirnezami R, Youssef J, Bronstein M, Laponogov I. HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods. Sci Rep. 2019 Jul 3;9(1):9237.
Koumpa FS, Xylas D, Konopka M, Galea D, Veselkov K, Antoniou A, Mehta A, Mirnezami R. Colorectal Peritoneal Metastases: A Systematic Review of Current and Emerging Trends in Clinical and Translational Research. Gastroenterol Res Pract. 2019 Apr 1;2019:5180895.
Poynter L, Galea D, Veselkov K, Mirnezami A, Kinross J, Nicholson J, Takáts Z, Darzi A, Mirnezami R. Network Mapping of Molecular Biomarkers Influencing Radiation Response in Rectal Cancer. Clin Colorectal Cancer. 2019 Jun;18(2):e210-e222.
Chand M, Keller DS, Mirnezami R, Bullock M, Bhangu A, Moran B, Tekkis PP, Brown G, Mirnezami A, Berho M. Novel biomarkers for patient stratification in colorectal cancer: A review of definitions, emerging concepts, and data. World J Gastrointest Oncol. 2018 Jul 15;10(7):145-158.
Wafi A, Mirnezami R. Translational -omics: Future potential and currentchallenges in precision medicine. Methods. 2018 Dec 1;151:3-11.
Mirnezami R, Ahmed A. Surgery 3.0, artificial intelligence and the next-generation surgeon. Br J Surg. 2018 Apr;105(5):463-465.
Veselkov K, Sleeman J, Claude E, Vissers JPC, Galea D, Mroz A, Laponogov I, Towers M, Tonge R, Mirnezami R, Takats Z, Nicholson JK, Langridge JI. BASIS: High-performance bioinformatics platform for processing of large-scale mass spectrometry imaging data in chemically augmented histology. Sci Rep. 2018 Mar 6;8(1):4053.
Laponogov I, Sadawi N, Galea D, Mirnezami R, Veselkov KA. ChemDistiller: an engine for metabolite annotation in mass spectrometry. Bioinformatics. 2018 Jun 15;34(12):2096-2102.
Bhome R, Goh RW, Bullock MD, Pillar N, Thirdborough SM, Mellone M, Mirnezami R, Galea D, Veselkov K, Gu Q, Underwood TJ, Primrose JN, De Wever O, Shomron N, Sayan AE, Mirnezami AH. Exosomal microRNAs derived from colorectal cancer-associated fibroblasts: role in driving cancer progression. Aging (Albany NY). 2017 Dec 28;9(12):2666-2694.