Professor Giuseppe Kito Fusai

MS, FRCS

Consultant Hepato-Pancreato-Biliary (HPB) Surgeon

After qualifying at the University of Milan in 1987 and obtaining a Master of Surgery from the University of Parma in 1992, I moved to the UK in 1995 and in 1996 I became a Fellow of the Royal College of Surgeons of Edinburgh.

Since then, I worked and trained in several centres of excellence for the treatment of HPB conditions, including Nagoya University Hospital, very well known for the management of hilar cholangiocarcinoma.

I have practiced this type of surgery for over thirty years and I have been a HPB Consultant Surgeon since 2008, performing more nearly 2000 major HPB surgeries with a perioperative mortality of 1,7% well below the National and International standards for both liver and pancreatic surgery.

Current NHS Post: Royal Free Hospital – HPB & Liver Transplant Unit

Current Leadership position(s):

Past President of Italian Medical Society of Great Britain
Chair of HPB Surgery

Personal profile:

I am married with two children. I have a charity called Fiorina, for the treatment and research on Pancreatic Cancer, which has supported several projects over the last 12 years. I am a past President of the Italian Medical Society.

Hospital Locations

Royal Free Hospital

Languages spoken

English, Italian

Specialities

General Surgery
HPB surgery
Neuroendocrine Tumours (NETs)

Memberships

BMA
AUGIS
ASGBI
E-AHPBA and IHPBA
ESA
ISGPS

Registration and licensing

GMC:4147143

Procedures offered

Biliary reconstruction
Decompressive pancreatic surgery for chronic pancreatitis
Distal and total pancreatectomy
Laparoscopic cholecystectomy (gallbladder removal)
Liver resection (hepatectomy)
Liver transplant surgery
Whipple pancreato-duodenectomy
Vascular reconstruction

Clinical interests

Cholangiocarcinoma (Bile duct cancer)
HPB surgery
Liver cancer and metastases
Liver transplants
Neuroendocrine tumours (NETs)
Pancreatic cancer
Second opinions - approximately 1 in 5 patients operated comes from second opinions provided for patients deemed inoperable in other centres

Research interests

Over the last few years I have been part and led several international multicentre projects, including the “arterial study for patients with locally advanced pancreatic cancer” and “Orange II plus” a randomised controlled trial comparing laparoscopic versus open hemi-hepatectomy.

Published papers

Published and co-authored approximately 200 peer-reviewed papers.

ClassenM, Cremer M, Faustini S, Meiser G, zum Buschenfelde M, Neuhaus H, Ott R, Pizzi P, Salvini A, Fusai GK, Staritz M et al. Electromagnetic shock-wave lithotripsy of gallbladder calculi. Multicentred preliminary report on experience with 276 patients. Hepatogastroenterology 1990; 37 (4): 425-7
Salvini A, Pizzi P, Faustini S, Baresi A, Fusai GK, Lochis D. Study of gallbladder motility after ESWL for cholelithiasis. Italian Journal of Digestive Endoscopy 1991; 14: 168
Viani MP, Poggi RV, Pinto A, Fusai G, Andreani SM, Maruotti RA. Gasless laparoscopic gastrostomy Journal of Laparoendoscopic Surgery 1995; 5 (4): 245 – 249.
Jenkinson AD, Scott SM, Yazaki E, Fusai G, Walker SM, Kadirkamanathan SS, Evans D. Compliance measurements of lower oesophageal sphincter and oesophageal body in achalasia and gastro-oesophageal reflux disease. Digestive Diseases & Sciences 2001; 46 (9): 1937 – 42.
Hoh IM, Fusai G, Bhattacharya S. Adult intussusception caused by Peutz-Jeghers hamartoma – an unusual presentation. Grand Rounds 2003; 3: 6-7
Fusai G and Davidson BR. Management of colorectal liver (lung) metastases [review] Colorectal Disease 2003; 5 (1): 2-23.
Fusai G and Davidson BR. Strategies to increase resectability of liver metastases from colorectal cancer [review]. Digestive Surgery 2003; 20: 1-16
Rolles K, Fusai G, Rolando N, Koti R, Patch D, Davidson B, Burroughs A. Endoscopic biliary stenting facilitates safe and early removal of T-tube in liver transplant patients. Minerva Chirurgica 2005; 60: 1-5
Fusai G, Glantzounis G, Hafez T, Wang W, Sheth H, Kanoria S, Parks HG, Seifalian A, Davidson BR. N-Acetylcysteine ameliorates the late phase of liver ischemia-reperfusion injury in an experimental animal model with fatty liver. Clinical Science 2005; 109(5):465-73
Fusai G, Tucker O, Karani J, Heaton N, Portmann B, Rela M. Peribiliary cysts can mimic Caroli’s disease. International Journal of Surgical Pathology 2005; 13(4):379-82
Fusai G, Steinberg R, Prachalias A, Heaton ND, Spitz L, Rela M. Ex-vivo liver surgery for extra-adrenal pheochromocytoma Pediatric Surgical International 2005; 22: 12-16
Beal I, Anthony A, Papadopolou G, Fusai G, Hutchins R, Davies N, Begent R, Tibbals B, Davidson BR. The effects of chemotherapy in patients undergoing portal vein embolization prior to hepatic resection for colorectal liver metastases. British Journal of Radiology 2006; 79(942): 473-8.
Fusai G, Dhaliwal P, Rolando N, Sabin C, Patch D, Davidson BR, Rolles K, Burroughs AK. Incidence and risk factors for severe and prolonged intrahepatic cholestasis following orthotopic liver transplantation: a multivariate analysis Liver Transplantation 2006; 12(11):1626-33
Kumar S, Fusai G Laparoscopic cholecystectomy in situs inversus totalis with left sided gallbladder Annals of Royal College of Surgeons of England 2007; 89(2):16-8
Fusai G, Warnaar N, Sabin CA, Archibong S, Davidson BR. Outcome of R1 resection in patients undergoing pancreato-duodenectomy for pancreatic cancer European Journal of Surgical Oncology 2008; 34(12):1309-15
Gurusamy KS, Samraj K, Fusai G, Davidson BR. Early versus delayed laparoscopic cholecystectomy for biliary colic. Cochrane Database Systematic Review 2008; 8(4): CD007196
Pine JK, Fusai G, Young R, Sharma D, Davidson BR, Menon KV, Rahman SH. Serum C-reactive protein concentration and the prognosis of ductal adenocarcinoma of the head of the pancreas. European Journal of Surgical Oncology 2009; 35(6): 605-10
Pamecha V, Glantzounis G, Biswas A, Fusai GK, Sharma D, Davies N, Davidson BR Long-term survival and disease recurrence after preoperative portal vein embolization prior to major hepatectomy for colorectal cancer liver metastases Annals of Surgical Oncology 2009; 16(5): 1202-7
Gurusamy KS, Samraj K, Fusai G, Davidson BR. Robot assistant for laparoscopic cholecystectomy. Cochrane Database Systematic Review 2009; 21(1): CD006578
Gurusamy KS, Koti R, Fusai G, Davidson BR Somatostatin Analogues for pancreatic surgery Cochrane Database Systematic Review 2010; 2: CD008370
Gurusamy KS, Samraj K, Ramamoorthy R, Farouk M, Fusai G, Davidson B Miniport versus standard ports for laparoscopic cholecystectomy. Cochrane Database Systematic Review 2010; 3: CD006804
Hafez TS, Glantzounis G, Fusai G, Taanman JW, Wignarajah P, Parkes H, Fuller B, Davidson BR, Seifalian A Intracellular oxygenation and cytochrome oxidase C activity in ischemic preconditioning in steatotic rabbit liver American Journal of Surgery 2010; 200(4): 507-18
Gurusamy KS, Koti R, Fusai G, Davidson BR Meta-analysis of randomized controlled trials on the effectiveness of somatostatin analogues for pancreatic surgery: a Cochrane review HPB (Oxford) 2010; 12(3): 155-65
Gurusamy KS, Bong JJ, Fusai G, Davidson BR. Methods of cystic duct occlusion during laparoscopic cholecystectomy. Cochrane Database Systematic Review 2010; 6(10): CD006807
Biochemical indicators of in-hospital complications after pancreatic surgery John BJ, Wijeyekoon S, Warnaar N, Shasi P, Rahman SH, Davidson BR, Fusai G International Surgery 2010; 95(3): 215-20
Gonzales H, Wei Liu Z, Cashman S, Fusai G Small for size syndrome following living donor and split liver transplantation World Journal of Gastrointestinal Surgery 2010; 2(12): 389-94
Dhaliwal P, Fusai G, Glantzounis G, Sabin C, Rolando N, Patch D, Sharma D, Davidson BR, Rolles K, Burroughs AK Risk factors associated with early hepatic artery thrombosis after orthotopic liver transplantation – a multivariable analysis Transplant International 2011; 24(4):401-8
Damrah O, Naik P, Fusai G, Sharma D. Is laparoscopic cholecystectomy safe for acute cholecystitis in the presence of ventriculo-peritoneal shunt? Int J Surg Case Rep 2011; 2(6):157-8
Rindi G, Falconi M, Klersy C, Albarello L, Boninsegna L, Buchler MW, Capella C, Caplin M, Couvelard A, Doglioni C, Delle Fave G, Fischer L, Fusai G, de Herder WW, Jann H, Komminoth P, de Krijger RR, La Rosa S, Luong TV, Pape U, Perren A, Ruszniewski P, Scarpa A, Schmitt A, Solcia E, Wiedenmann B. TNM staging of neoplasms of the endocrine pancreas: results from a large international cohort study. J Natl Cancer Inst. 2012;104(10):764-77
Kanoria S, Glantzounis G, Quaglia A, Dinesh S, Fusai G, Davidson BR, Seifalian AM. Remote preconditioning improves hepatic oxygenation after ischaemia reperfusion injury. Transpl Int. 2012;25(7):783-91
Gurusamy KS, Koti R, Fusai G, Davidson BR. Somatostatin analogues for pancreatic surgery. Cochrane Database Systematic Review. 2012; 13;6:CD008370
Gurusamy KS, Samraj K, Fusai G, Davidson BR. Robot assistant versus human or another robot assistant in patients undergoing laparoscopic cholecystectomy. Cochrane Database Syst Review. 2012; 12;9:CD006578.
Mouralidarane A, Soeda J, Visconti-Pugmire C, Samuelsson AM, Pombo J, Maragkoudaki X, Butt A, Saraswati R, Novelli M, Fusai G, Poston L, Taylor PD,Oben JA. Maternal obesity programs offspring nonalcoholic fatty liver disease by innate immune dysfunction in mice. Hepatology. 2013; 58(1):128-38.
John BJ, Naik P, Ironside A, Davidson BR, Fusai G, Gillmore R, Rahman SH. Redefining the R1 resection for pancreatic ductal adenocarcinoma: tumour lymph nodal burden and lymph node ratio are the only prognostic factors associated with survival HPB (Oxford). 2013;15(9):674-80
Ravikumar R, Holroyd D, Fusai G. Is there a role for arterial reconstruction in surgery for pancreatic cancer? World J Gastrointest Surg. 2013; 27: 5(3): 27-9
Gurusamy KS, Koti R, Fusai G, Davidson BR. Somatostatin analogues for pancreatic surgery. Cochrane Database Syst Rev. 2013; 30;4
Gurusamy KS, Koti R, Fusai G, Davidson BR. Early versus delayed laparoscopic cholecystectomy for uncomplicated biliary colic. Cochrane Database Syst Rev. 2013; 30;6
Gurusamy KS, Vaughan J, Ramamoorthy R, Fusai G, Davidson BR. Miniports versus standard ports for laparoscopic cholecystectomy. Cochrane Database Syst Rev. 2013; 1;8
Preziosi G, Oben J, Fusai G The role of hyperinsulinemia as a risk factor for pancreatic cancer J Cancer Ther 2013; 4:10-16
Coolsen MM, Clermonts SH, van Dam RM, Winkens B, Malagó M, FusaiGK, Dejong CH, Olde Damink SW. Development of a Composite Endpoint for Randomized Controlled Trials in Pancreaticoduodenectomy. World J Surg. 2013 Dec 24. [Epub ahead of print]
Portal Vein Resection in Borderline Resectable Pancreatic Cancer: a UK Multicentre Study. Ravikumar R, Sabin C, Abu Hilal M, Bramhall S, White S, Wigmore S, Imber C, Fusai G on behalf of the UK Vascular Resection in Pancreatic Cancer Study Group. J Am Coll Surg. 2014 Mar;218(3):401-11.
Kasivisvanathan R, Abbassi-Ghadi N, Prout J, Clevenger B, Fusai GK, Mallett SV. A prospective cohort study of intrathecal versus epidural analgesia for patients undergoing hepatic resection. HPB (Oxford). 2014 Jan 28. doi: 10.1111/hpb.12222. [Epub ahead of print]
Keane G, Bramis K, Pereira S, Fusai G A systematic review of novel methods of cytoreduction in locally advanced and metastatic pancreatic cancer. World Journal of Gastroenterology (WJG ) 2013 (in press)
Lykoudis P, O’Reilly D, Nastos K, Fusai G Timing of surgical management of synchronous colorectal liver metastases: first, simultaneous or last? A systematic review on current literature British Journal of Surgery (BJS) 2013 (in press) DOI 10.1002/bjs.9449
Puri Y, Lytras D, Luong TV, Fusai GK Rare presentation of self-resolving multifocal inflammatory pseudo-tumour of liver. World J Clin Cases. 2014 Jan 16;2(1):5-8
Gurusamy K, Kumar S, davidson BR, Fusai G Resection versus other treatments for locally advanced pancreatic cancer Cochrane Database Syst Rev. 2014; Issue 2. CD010244
Preziosi G, Fusai G Obesity and pancreatic cancer Surg Oncol 2014; 23(2):61-71.
Ravikumar R, Fusai G Preoperative Gemcitabine-Baseb Chemoradiation Therapy for Resectable and Borderline Resectable Pancreatic Cancer. Letter to the Editor Ann Surg 2014, May 12
Vyas SJ, Davies N, Grant L, Imber CJ, Sharma D, Davidson BR, Malago M, Fusai G. Failure of Portal Venous Embolization. ALPPS as Salvage Enabling Successful Resection of Bilobar Liver Metastases. J Gastrointest Cancer. 2014 (in press)