Dr Aaron Hughes

MBBS BSc MRCP PhD

Consultant Dermatologist

Dr Aaron Hughes is a Consultant Dermatologist with recognised expertise in psoriasis, eczema and male genital rashes.

Dr Hughes trained across London's most prestigious teaching hospitals, including the Royal Free Hospital, St George's Hospital, Guy's & St Thomas' and University College London Hospitals NHS Foundation Trust (UCLH). He spent 3 years researching the mechanisms behind eczema and received a PhD for this work. Dr Hughes undertook additional training in male genital skin conditions at UCLH and set up a specialist clinic for these patients at the Royal Free Hospital.

At the Royal Free Hospital Dr Hughes is a supervising consultant in the specialist psoriasis clinic, and the lead for clinical governance in the Dermatology department.

Dr Hughes has over 20 academic publications and has presented research internationally in Amsterdam, Milan, Berlin and Madrid. He has received numerous prizes and academic awards for his work, including a competitive grant from the Medical Research Council.

Hospital Locations

Royal Free Hospital, Hadley Wood Hospital

Year qualified

2012

Country of qualification

Languages spoken

English

Specialities

Dermatology

Memberships

British Association of Dermatologists
General Medical Council
Royal College of Physicians
British Society for Medical Dermatology
European Academy of Dermatology and Venerology

Registration and licensing

GMC:7304042

Procedures offered

Mole and Cyst excision (removal)
Shave or Curette and Cautery
Punch biopsy
Hyfrecation
Cryotherapy
Steroid injection

Clinical interests

Male Genital Dermatology
Lichen Sclerosus
Psoriasis, Eczema and other inflammatory skin conditions
Acne/Rosacea
Moles

Research interests

Eczema
Psoriasis
Male genital Dermatology

Published papers

AJ Hughes, L Coppock, T TachieMenson, BR Thomas, P Dewan, I Doykov, K Mills , EA O’Toole, RFL O’Shaughnessy. Reduced Filaggrin expression induces dysregulated intracellular signalling in atopic eczema, BioRxiv 2024.03.11.584344
Theresa Tachie-Menson, Aaron Hughes, Edel O’Toole, Ryan O’Shaughnessy, P15 Understanding the role of cathepsin H in atopic dermatitis pathogenesis, British Journal of Dermatology, Volume 190, Issue 6, June 2024, Pages e85–e86
Hughes AJ, Barbosa E, Cernova J, Thomas BR, O'Shaughnessy RFL, O'Toole EA. Loss of Function Filaggrin Mutations are Associated with Reduced History of Acne Vulgaris in a Cohort of Bangladeshi Atopic Eczema Patients in East London. Clin Exp Dermatol. 2024 May 15:llae185. doi: 10.1093/ced/llae185. May 2024. PMID: 38747172.
McCarthy RL, Tawfik SS, Theocharopoulos I, Atkar R, McDonald B, Dhoat S, Hughes A, Thomas B, O’Toole E. Vitamin D deficiency and atopic dermatitis severity in a Bangladeshi population living in East London: a cross-sectional study. Skin Health Dis. March 2024;e358.
Tachie-Menson T, Azizah A, Hughes A and O'Shaughnessy R (2023). P27 Uncovering the roles of lysosomal protease cathepsin H in atopic dermatitis. Oxford University Press (Oup) British Journal of Dermatology vol. 189, (1) e24-e25. 10.1093/bjd/ljad174.048
Hughes A, Barbosa E, Cernova J, Thomas B, O’Toole E and O'Shaughnessy R (2023). P102 Severe atopic eczema is associated with reduced acne vulgaris in Bangladeshi children and young adults: a retrospective analysis from a cross-sectional study. Oxford University Press (Oup) British Journal of Dermatology vol. 188, (Supplement_4) 10.1093/bjd/ljad113.130
Rebecca L McCarthy, Bjorn R Thomas, Soha S Tawfik, Ravinder Atkar, Bryan McDonald, Sasha Dhoat, Aaron Hughes, Edel O’Toole, PA07 (P65) Vitamin D deficiency is associated with atopic dermatitis severity in a Bangladeshi population living in the UK, British Journal of Dermatology, Volume 188, Issue Supplement_4, June 2023
Tachie-Menson T, Azizah A, Hughes A and O'Shaughnessy R (2023). 770 AKT1- dependent protease control of skin barrier function and inflammation in atopic dermatitis. Elsevier Journal of Investigative Dermatology vol. 143, (5) 10.1016/j.jid.2023.03.779
Thomas BR, Tan XL, Van Duijvenboden S, Hogan SC, Hughes AJ, Tawfik SS, Dhoat S, Atkar R, Robinson EJ, Rahman SR, Rahman S, Ahmed RA, Begum R, Khanam H, Bourne EL, Wozniak EL, Mein CA, Kelsell DP, O'Toole EA. Deep palmar phenotyping in atopic eczema: patterns associated with filaggrin variants, disease severity and barrier function in a South Asian population. Br J Dermatol. 2023 May 24;188(6):785-792. doi: 10.1093/bjd/ljad036. PMID: 36840480.
Hughes AJ, Thomas B, O'Toole EA, O'Shaughnessy R. Reduced FLG expression in atopic eczema reduces expression of key barrier genes and increases BMP signalling JOURNAL OF INVESTIGATIVE DERMATOLOGY. 142: S211- S211. Dec 2022
Tawfik S, Baruah K, Hughes A, Thomas B, O-Shaughnessy R, Toole EO. Carbonylated proteins as markers of oxidative stress and their association with filaggrin genotype in atopic eczema BRITISH JOURNAL OF DERMATOLOGY. 187: 14-14. Jul 2022
Hughes A, Thomas B, O'Toole E, O'Shaughnessy R. Reduced filaggrin expression is associated with increased BMP signalling BRITISH JOURNAL OF DERMATOLOGY. 186: E221-E222. Jun 2022
Hughes AJ, Thomas B, O'Toole EA, O'Shaughnessy R. Increased BMP Signalling Correlates with Increased Eczema Severity JOURNAL OF INVESTIGATIVE DERMATOLOGY. 141: S170-S170. Oct 2021
Hughes AJ, Tawfik SJ, Baruah KP, O’Toole EA, O’Shaughnessy RFL. Tape Strips in Dermatology Research. Br J Dermatol. 2021 Jul;185(1):26-35. PMID: 33370449.
Bhadresha S, Hughes AJ, McMahon L, Reeken S, Natkunarajah J. Fixed drug eruption secondary to Adalimumab. Clin Exp Dermatol. 2021 Mar;46(2):366- 368. PMID: 33448464.
Frewen J, Hughes AJ, Denny J, Narkunarajah N. Lipodermatosclerosis of the penduolous abdomen. Clinical and Experimental Dermatology. 2020 Jul;45(5):626-627. PMID: 32141633
Shuber E, Hughes AJ, Natkunarajah J. Giant Scabetic Plaques. Clinical and Experimental Dermatology. 2020 Jul;45(5):587-589. PMID: 31749248
Qureshi F, Hughes AJ, Natkunarajah J. Methotrexate for Papuloerythroderma of Ofuji. Clinical and Experimental Dermatology. 2020 Mar;45(2):241-243. PMID: 31111514
Hughes A, Samarasinghe V, Abdul-Wahab A. Chronic knee ulcer secondary to Staphylococcus lugdunensis. Australasian Journal of Dermatology. 2019 Nov;60(4):325-326. PMID: 30982946
Hughes A, French M, Ah-Weng A, Singh M. Diffuse and strong TTF-1 positivity in a combined Merkel cell carcinoma. American Journal of Dermatopathology. Am J Dermatopathol. 2020 Mar;42(3):229-231. PMID: 31107682.
Hughes A, Tull TJ, Semkova A, Calonje E, Stefanato CM. An enlarging nodule on the shin. Clinical and Experimental Dermatology. 2018 Jul;43(5):627-629. PMID: 29508412
Hughes A. Infections of the Skin: core reading material and associated higher order thinking assessments for the Postgraduate Diploma in Dermatology: Middlesex University, London and Rila Institute of Health Sciences, London (2017)
Aref-Adib M, Lambd B W, Lee H B, Akinnawo E, Raza M M A, Hughes A, Mehta V S, Odonde I R, Yoong W. Stem cell therapy for stress urinary incontinence: a systematic review in human subjects. Archives of Gynaecology and Obstetrics. 2013; 266(6), 1213-1221. PMID: 24077813 Hughes A. Making the most of Foundation Year 1. BMJ Careers. 2013 (August 23 rd )
Hughes A, Hoffman J and Hoffman A. Vitamin D and sun exposure: to bare all or cover up?. Expert Review of Dermatology. 2012; 7(6), 495-497
Hughes A. Sunscreens: more harm than good? A controversy worth addressing. Expert Review of Dermatology. 2012; 7(2), 113-115

Dr Aaron Hughes, Consultant Dermatologist is available to be seen for consultations at Royal Free Hospital and Hadley Wood Hospital

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