Professor Daniel Gale


St Peter’s Professor Of Nephrology

I conduct research into genetic kidney disease and run the genetic kidney disease clinical service for North London that provides care for patients and families with hereditary kidney problems, including Polycystic Kidney Disease, Alport Syndrome, unexplained familial kidney failure, complement disorders and other genetic conditions. Patients are frequently offered enrolment in clinical research studies, including those involving new treatments.

Using linkage mapping, next generation sequencing and other techniques I discovered (and identified the genetic defects responsible for) the diseases HIF2α erythrocytosis and pulmonary hypertension, which results from a defect in cellular oxygen sensing, and CFHR5 nephropathy, which results from a defect of complement alternative pathway regulation and which is endemic in people of Cypriot ancestry. I also study genetic factors important in other kidney diseases and, using genome wide association studies, have identified the genes important in a range of more common kidney diseases, including IgA nephropathy and Steroid Sensitive Nephrotic Syndrome.

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Hospital Locations

Royal Free Hospital

Year qualified


Country of qualification


Languages spoken



  • Nephrology


  • Fellow of the Royal College of Physicians
  • Member of the Association of Physicians of UK and Ireland
  • Member of the Renal Association

Registration and licensing


Special interests

  • Genetic kidney diseases
  • Polycystic kidney disease
  • Alport Syndrome
  • Microscopic haematuria
  • Thin basement membrane nephropathy
  • Familial kidney disease
  • MPGN
  • C3 glomerulopathy

Professor Daniel Gale, St Peter’s Professor Of Nephrology is available to be seen for consultations at Royal Free London